For acne scars
Moderate evidenceA 2025 systematic review of 16 studies (481 patients, including 6 RCTs) concluded RF microneedling is likely effective as monotherapy for atrophic acne scars over a typical 3 to 4 session course. However, a 2026 meta-analysis of 8 randomized trials (249 patients) found fractional CO2 laser produced greater scar improvement and higher patient satisfaction than RF microneedling, so it is a solid second-line choice, often picked for darker skin where CO2 carries more pigmentation risk.
Randomized trials support this use, but they are few, small, or short. The effect is probably real. The size of it is less certain.
- Fractional Radiofrequency Microneedling as a Monotherapy in Acne Scar Management: A Systematic Review of Current Evidence (Clinical, Cosmetic and Investigational Dermatology, 2025; systematic-review)
- Fractional CO2 Laser Versus Micro Needling Radiofrequency for Post Acne Scarring: A Meta-Analysis of RCTs (Journal of Cosmetic Dermatology, 2026; meta-analysis)